DNA Diet

Tests for:

Genes that impact metabolism, insulin sensitivity, satiety and feeding behaviour.

Analytes measured:

Absorption and Metabolism

FABP2:  Influences fat absorption and metabolism.
PPARG: Involved in adipocyte differentiation. It is a transcription factor activated by fatty acids, and is also involved in the regulation of glucose and lipid metabolism.
ADRB2:  Involved in the mobilisation of fat from fat cells for energy, in response to catecholamines.
APOA5: Plays an important role in regulation of plasma triglycerides.

Fat Metabolism, Obesity and Satiety

APOA2: An abundant apolipoprotein in HDL. Plays a complex role in lipoprotein metabolism, insulin resistance, obesity and atherosclerosis susceptibility.

Regulation of Metabolism and Feeding Behaviour

MC4R: A strong obesity candidate gene, significantly associated with energy intake and expenditure.

Insulin Sensitivity and Regulation of Energy Intake

FTO: Involved in the regulation of arousal, appetite, temperature, autonomic function and  endocrine system.
TCF7L2: Regulates blood glucose homeostasis, influencing both insulin secretion and sensitivity.

Exercise Responsiveness

ADBR3: Involved in the regulation of lypolysis that influences metabolism.

Circadian Rhythms

CLOCK: An essential regulatory arm of the biological clock, involved in metabolic regulation.

Fat Storage

PLIN: Influences diet-induced obesity.

Inflammation

TNF-A: TNFa is a pro-inflammatory cytokine, secreted by both macrophages and adipocytes, which has been shown to alter whole body glucose homeostasis, and has been implicated in the development of obesity, obesity-related insulin resistance and dyslipidemia.

Carbohydrate Sensitivity and Eating Behaviour

TAS1R2: Believed to contribute to the inter-individual variation in sugar consumption.
SLC2A2 (GLUT2): Influences the first step in glucose induced insulin secretion, affecting both food intake  and regulation.
DRD2: Midbrain dopamine circuits may play an important role in both addiction and normal eating behaviour as they are involved in reward processing, particularly dopaminergic signalling via dopamine receptor 2 (DRD2).